Reducing The Impact of Malaria Plaguing Africa and Some Other Parts of The World

Introduction 

Malaria has become a major pandemic in the global stretch affecting people mainly in Africa. Malaria is a killer disease in Africa amidst the efforts to reduce the infection rates and mortality rates. The United Nations Children’s Funds (UNICEF) identified that malaria spread in more than 100 countries across the world. The most affected areas were largely the less-developed tropical areas of Africa, Asia, and Latin America. The disease killed more than one million people every year in Africa. the globe records more than 300 million cases of malaria where 90% occurred in sub-Saharan Africa. the World Health Organization (WHO) reports that malaria is responsible for one to five deaths in children below five years in Africa. 

The impacts of malaria are seen in the death of the victims, the medical costs, income deterioration, and reduced economic growth. The direct and indirect costs of malaria in Africa are estimated to be more than $2 billion as revealed by the WHO. Malaria has for a long time been considered a consequence of poverty. Today, it is regarded as the cause of poverty following its toll on families and the economy. Experts in medical science and research admit that malaria slows down economic growth by up to 1.3% every year. The rural people are often at high risk as they are less likely to have the means to prevent and treat malaria. The children usually miss their education sessions and suffer physical and mental trauma. Most people affected by malaria cannot contribute to the income of their households. A report by WHO implies that families spend a quarter of their annual income to treat the disease. 

Global Health Topic

Malaria is a disease caused by a mosquito bite. This mosquito-borne infectious illness affects humans across the world. It is caused by a protozoan parasite that belongs to the genus Plasmodium. There are four species of this parasite that are accountable for all human infections. However, the species P falciparum has the most infection in Africa and responsible for the severity of the disease with high rates of mortality. 

The risks for malaria and its epidemics grow with the growth in climate and it changes with the activities such as mining, logging, road construction, and irrigation among other activities. The4se changes increase the breeding sites of malaria-transmitting mosquitoes and as a result, promote the transmission of the disease (Mbah et al., 2014). The military conflicts can also result in the spread of the disease as people are forced into the new areas of exposure and limiting the access to prevention and treatment centers. The movement of the nonimmune persons places them at high risks and allows malaria to re-emerge in the places where it was previously in control. The declining health services and increasing drug resistance also contributes to the spread of malaria. 

 Individuals can protect themselves against malaria by wearing protective clothing and using the insects to repel and bed nets. The World Health Organization posits that the field trials show insecticide-related bed nets and curtains that can reduce childhood mortality by 15% to 35%. Despite the proven efficiency, less than 2% of the children in Africa who sleep under protective bed nets get infected (Kakuru et al., 2019). There are drugs used to prevent and treat infections in people. The increasing use of chloroquine-resistant malaria has called for the need for new drugs. Use-friendly medicine packaging also makes sure the patients take medicines as per the physician’s prescription. Better compliance helps with the prevention of the development of drug-resistant malaria. While many new antimalarial drugs have been developed over the last 20 years and there is a need for an affordable, effective, safe alternative to chloroquine. 

In 1998, the WHO, the United Nations Development Program (UNDP), UNICEF, and the World Bank started global roll-back malaria (RBM) partnership. In 2010, the coalition of the governments developed agencies commercial organizations, research groups, and the media sought to eliminate the world incidences of malaria. The focus of this tier was on

• Early diagnosis and fast treatment
• Insecticide-treated bed nets and vector control
• Malaria treatment for pregnant women
• Prevention and response to the epidemics

The global efforts saw the medicines for malaria venture aiming to discover and develop the new antimalarial drugs. These would then be made accessible in developing countries. The private and public partnerships brought together the expertise in the drug industry with the experiences of the public sector (Kula, Haines & Fryatt, 2013). The WHO works with the Swiss pharmaceuticals to offer people in the malaria-endemic countries the antimalarial combination drug Coartem at low prices. Today, there are different vaccines developed and there is hope that in the coming decade, there will be one vaccine that will be deemed effective for battling malaria. 

The Miasma Theory

In the 95BC, Lucrctius presented a hypothesis that swamp fever may occur from a living organism. In the 19th century, there was a theory that fevers from Italian malaria were caused by poisonous vapor or miasma from the swamps. Climate seasons and geographical location were thought to be an influence of fevers that were referred to as paludal. There were findings that not all the swamps were bound to cause malaria and fevers (Hempelmann & Krafts, 2013). In the 1800s, scientists launched rallies behind the animalcular theory, the precursor of the germ theory that emerged later. A breakthrough on the topic emerged in 1800 with the discovery of the malaria parasite by physician Charles Louis Alphonse Laveran. Despite the discovery of the plasmodium falciparum, the scientific community continued to be skeptical. 

It was until 1887 that William Osler gave credit to the theory by Laveran and acknowledged that the parasite was pathogenic and its ecology was associated with the disease. In 1897, Ronald Ross started an investigation after he was motivated by Patrick Manson. They investigated the hypothesis that female pigmented crescents of the parasite are seen on the wall of the stomach of the mosquito Anopheles Stephensi. According to Ross, the sporozoites of the plasmodium exist in the digestive system. 

The miasma theory was revisited and viewed from the perspective of knowledge in modern science. In the earlier periods, fevers were believed to be caused by contagion and miasma. Contagion referred to the infections from person to person through the area by sneezing or breathing. Miasma referred to fever acquired from swamps or other water bodies (Friess, 2016). In these eras, the knowledge was useful in controlling the environmental issues of the European cities. The improvement in general environmental sanitation in Europe became instrumental in controlling communicable diseases. The miasma theory helped Europe develop its public health sector and the reason it became relegated to the background at the expense of the germ theory. 

Africa is currently the area most affected in the worse situation concerning public health. Environmental sanitation is a major issue that persistently deteriorates in Africa with attendant health implications. Communicable diseases are rampant including vector-borne infections such as malaria. The open drains, dumps, and stagnant water bodies exist in abundance in the different communities and encourage the breeding of mosquitoes. 

The physicians working on the malaria issue in the tropical and subtropical areas of the world have been confronted by the issue of treating supposed malaria fever in the same patient. The failure of the treatment is attributed to the development of resistance by the plasmodium in the blood. This has been approved in Nigeria, the observations are explained by the fact that most of the drugs are fake usually not containing the active ingredient in the expected pharmacological concentration of the tablets or capsules (Tzu et al., 2021). Other malaria attacks are explained by the recrudescence where plasmodium species re-enter the blood from a quiescent stage in the liver. The malaria recrudescence is explained when a victim from a malaria-endemic zone suddenly develops for malaria more than one year. The miasma theory can explain this malarial attack. The miasma theory explains that fevers are caused by inhalation of miasma. The demonstration of malaria parasites in the blood would not necessarily account for the associated fever. 

The Strain Theory

The debates on the number and nature of species that cause human malaria started in the 1920s. the idea started from the fact that the species consisted of varieties, strains, and races. There have been complex ideas developing the entities where they have been discrete, independent, and mutable. The traits differentiated them and how they affected the clinical and epidemiological observations and interventions (Abkallo et al., 2015). By the late 1970s, the cloning and cultivation of the P falciparum were possible, serologic and molecular techniques that rapidly developed. Some concepts emerged from the rise of the laboratory-based studies accompanied by a shift in the language “strain and race” that were displaced by “clone and isolate.” In the mid-1900s. the concept of strain emerged again in the anticipation of the vaccine protects against the subset of these parasites. 

The strain theory holds the assumption that malaria comprised discrete and independently transmitted entities. The theory also concludes that the control of malaria through vaccination may be far easier than previously assumed. The related theory was developed to explain the immunity to clinical malaria and to describe the immunity to the var gene product. Investigations on the strains in malaria were devoted to appreciating the parasite's phenotypes. However, rapid and reliable molecular techniques for determining parasite genotype were developed. It seemed clear that the strains can be differentiated with unprecedented precision directly by napping the genotypes to some of the smaller phenotype sets (Pilosof et al., 2019). Theories do not always detail the observations. Rather, they formulate the general principles that explain the different specific observations about the underlying entities. The theories explain the forces and links to allow the evidence to accumulate for or against the theory to explain the wider field. The pursuit of the strain is deemed essential to understanding the concept developed in the 19202-1970s regarding the different aspects of malaria. The concept is more of the immunology that is now the familiar distinction between the clinical and parasitology aspect of the response. 

 The results from the malaria therapy in the 1920s and 1930s in conjunction with the different influential malaria experiments in the birds and the non-human primates. It also includes the field observations in the malaria-endemic countries that produced general agreement within the species of the malaria parasite. Some races or strains can be identified as distinct by their clinical virulence, their infectivity, their reaction to the antimalarial remedies, and their antigenic properties (He et al., 2018). The characterization of race or strain is associated with strong practical disorientation. These are clinical virulence and reaction to antimalarial remedies that were considered important because of their therapeutic malaria infections that produce fevers and other symptoms at sufficient but not expensive levels. These need to be patient-reinfection and can be reliable and predictable. 

Critique 

Even though malarial sickness keeps on negatively affecting millions around the world, especially in sub-Saharan Africa, diverse arrangements and program endeavors are adequately tending to a portion of the difficulties presented by this infection. 

In Kenya, a public-private organization including work environment advancement of bed nets alongside finance buying plans for representatives at a concrete processing plant decreased jungle fever cases by 80% and emergency clinic confirmations by 90% in one year, as indicated by the World Bank (Korenromp et al., 2017). The African Medical and Research Foundation (AMREF), with financing from the global drug organization GlaxoSmithKline, made a bed-net industry by providing local gatherings with sewing machines and mesh material. Alongside the drop in jungle fever cases, there is less non-attendance at work, expanded usefulness, and decreased medical care costs. 

Various nations have decreased or taken out charges and taxes on mosquito nets and extras, including Cameroon, Côte d'Ivoire, Ghana, Kenya, Mozambique, Namibia, Nigeria, Tanzania, Uganda, and Zambia (Kabaria et al., 2017). At the state level in Nigeria, lead representatives are appropriating bed nets at financed costs, providing antimalarial tranquilizes for nothing to kids and pregnant ladies, and have apportioned assets to the intestinal sickness spending plan. Private-area banks and oil organizations are making bed nets accessible using a credit card for their representatives.

 In the mid-1990s, the public authority of Vietnam started a purposeful exertion to control intestinal sickness through the arrangement of free insect poison treated bed nets, the advancement of indoor splashing with insect sprays, and the utilization of privately created antimalarial drugs. From 1992 to 1997 the loss of life from intestinal sickness dropped by 97%, and the quantity of jungle fever cases fell by right around 60%, as indicated by the WHO (Sauboin et al., 2015). These activities required significant interests in preparing, illness detailing frameworks, management, and volunteer wellbeing laborers.

 The WHO reports that in Tigray, northern Ethiopia, a local area-based program is utilizing more than 700 volunteers to instruct and give jungle fever medicine to more than 1.7 million individuals. More than three years, there has been a 40 percent drop in the passing of kids under age 5, and demise rates from intestinal sickness are a third lower in towns taking an interest in the program. 

A few potential immunizations are currently being developed, and there is trust that in the following seven to 15 years one will demonstrate viably. To be valuable in the fight against jungle fever, in any case, an immunization needs to give long-haul resistance just as be financially savvy (Barnes et al., 2005). Analysts at the Karolinska Institute in Sweden as of late distinguished the system by which the intestinal sickness parasite connects itself to the placenta in a pregnant lady. This data can help in the advancement of an antibody to secure moms in jungle fever endemic regions. 

Other global endeavors to control intestinal sickness are zeroing in on hereditarily adjusting the jungle fever conveying mosquito, planning the intestinal sickness genome, and restricting the jungle fever parasite from going from the gut of the mosquito to its spit.

Conclusion 

The risks for malaria and its epidemics grow with the growth in climate and it changes with the activities such as mining, logging, road construction, and irrigation among other activities. Individuals can protect themselves against malaria by wearing protective clothing and using the insects to repel and bed nets. Africa is currently the area most affected in the worse situation concerning public health. Environmental sanitation is a major issue that persistently deteriorates in Africa with attendant health implications. The strain theory holds the assumption that malaria comprised discrete and independently transmitted entities. The theory also concludes that the control of malaria through vaccination may be far easier than previously assumed. The theories explain the forces and links to allow the evidence to accumulate for or against the theory to explain the wider field. The characterization of race or strain is associated with strong practical disorientation.

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